What relevance does the question of a minimal genome have to the creation/evolution debate? Consider the original creation. There would have been no parasites or diseases. In the post-fall world, organisms had to adapt to these lifestyles. One way they could do that is ejecting genes that they no longer needed. Hence essentially minimizing their genome. This is why I expect that no universal minimal genome will ever be found. Each kind requires unique genes to accomplish its various tasks.